Antibiotic sensitivity and mutation rates to antibiotic resistance inMycoplasma mycoidesssp.mycoides

Mutation frequencies and antibiotic resistance.

Antibiotic resistance can be achieved by horizontal acquisition of resistance genes (carried by plasmids or transposons), by recombination of foreign DNA into the chromosome, or by mutations in different chromosomal loci (15). In studies of molecular evolutionary biology, the term mutation rate is applied to estimations of the rate (per generation) of mutation per nucleotide, per locus, or, eve...

Antibiotic resistance and antibiotic sensitivity based treatment in Helicobacter pylori infection: advantages and outcome.

AIMS To compare two strategies for the eradication of Helicobacter pylori infection. METHODS Groups 1 and 2 each consisted of 75 consecutive patients. Patients in group 1 were treated with two antibiotics based on antibiotic susceptibility testing; those in group 2 received amoxycillin and clarithromycin for eight days, together with either ranitidine or omeprazole. Eradication rate was asses...

Inhibition of Mutation and Combating the Evolution of Antibiotic Resistance

The emergence of drug-resistant bacteria poses a serious threat to human health. In the case of several antibiotics, including those of the quinolone and rifamycin classes, bacteria rapidly acquire resistance through mutation of chromosomal genes during therapy. In this work, we show that preventing induction of the SOS response by interfering with the activity of the protease LexA renders path...

Strategies to Combat Antibiotic Resistance

Rationalizing antibiotic use to limit antibiotic resistance in India+

Antibiotic resistance, a global concern, is particularly pressing in developing nations, including India, where the burden of infectious disease is high and healthcare spending is low. The Global Antibiotic Resistance Partnership (GARP) was established to develop actionable policy recommendations specifically relevant to low- and middle-income countries where suboptimal access to antibiotics - ...